2. Apoptosis
  3. Bcl-2 Family
  4. OICR12694

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6).

For research use only. We do not sell to patients.

OICR12694 Chemical Structure

OICR12694 Chemical Structure

CAS No. : 2360625-97-2

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Other Forms of OICR12694:

OICR12694 Related Antibodies

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Description

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6)[1].

IC50 & Target

B cell lymphoma 6 (BCL6)[1]
Cellular Effect
Cell Line Type Value Description References
KARPAS-422 IC50
0.092 μM
Compound: 58
Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay
Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay
[PMID: 36793435]
Molecular Weight

645.03

Formula

C29H28ClF3N8O4
CAS No.
SMILES

O=C1C2=C(N=C3N1CCC3)N(CC(NC4=C(Cl)C(F)=NC(N5[C@H](CN(CC5)C)C)=C4)=O)C=C2C6=CC(C(N)=O)=C(C(F)=C6F)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OICR12694 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OICR126942360625-97-2JNJ-65234637OICR 12694OICR-12694JNJ65234637JNJ 65234637Bcl-2 FamilyInhibitorinhibitorinhibit

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HY-153096
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