Oleandrigenin

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Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na⁺/K⁺-ATP-ase inhibiting and cytotoxic activities.

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Oleandrigenin Chemical Structure

CAS No. : 465-15-6

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Description

Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na⁺/K⁺-ATP-ase inhibiting and cytotoxic activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 12	Viability of human A549 cells by MTT assay after 24 hrs Viability of human A549 cells by MTT assay after 24 hrs	[PMID: 17595134]
A549	IC₅₀	0.36 μM Compound: 12	Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr	[PMID: 17595134]
A549	IC₅₀	0.52 μM Compound: 12	Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr	[PMID: 17595134]
BJ	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
BJ	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
CCRF-CEM	IC₅₀	0.2 μM Compound: 2	Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
CCRF-CEM	IC₅₀	0.2 μM Compound: 2	Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
HeLa	IC₅₀	0.2 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
HeLa	IC₅₀	0.2 μM Compound: 2	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
MCF7	IC₅₀	0.8 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
MCF7	IC₅₀	0.8 μM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]

Molecular Weight

432.55

Formula

C₂₅H₃₆O₆

CAS No.

465-15-6

SMILES

O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86(15):10249-10262. [Content Brief]

[2]. Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520. [Content Brief]

Oleandrigenin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleandrigenin465-15-6Na+/K+ ATPaseSodium potassium pumpCEMMCF7HeLaBJ cellsInhibitorinhibitorinhibit

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