2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Olezarsen

Olezarsen  (Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx)

Cat. No.: HY-153491
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Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]

Olezarsen Chemical Structure

CAS No. : 2097587-83-0

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Other Forms of Olezarsen:

Olezarsen Related Antibodies

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apoE apoB apoC3

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Description

Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

IC50 & Target

apoC3

 

Clinical Trial
CAS No.
SMILES

[Olezarsen]
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Olezarsen Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olezarsen2097587-83-0ISIS 678354 IONIS-APOCIII-LRx AKCEA-APOCIII-LRxISIS678354ISIS-678354ApolipoproteinAPOC3TriglycerideInhibitorinhibitorinhibit

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