Cap Analogs

The “cap” structure (m7G[5']ppp[5']N, where N is any nucleotide) is present at the 5-end of eukaryotic mRNA molecules synthesized by RNA polymerase II. It typically consists of a 7-methylguanosine moiety attached via a 5-5 triphosphate bridge to the 5-terminal nucleoside of the RNA strand. The distinct cap structure plays a vital role in providing resistance to 5′‐exonuclease that helps to protect the mRNA from speedy degradation by 5′‐exonuclease activity. It has participated in numerous aspects of mRNA metabolism such as intracellular transport, splicing, subcellular localization, initiation of RNA, translation, and mRNA turnover. The use of the synthetic dinucleotide analog m7G[5']ppp[5']G has been the most common method for in vitro synthesis of 5-capped mRNAs. The presence of cap structure confers mRNA stability and enables efficient translation.

Cap 0 (8)
Cap 1 (11)

Cap Analogs (32):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-139100B

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium	75252-10-7	98.82%
N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription.

Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with adenosine, diammonium salt Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with adenosine, diammonium salt

HY-145974A

m7GpppAmpG ammonium		≥99.0%
m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90%.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methyladenylyl-(3′→5′)-, inner salt, ammonium Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methyladenylyl-(3′→5′)-, inner salt, ammonium

HY-145973A

3'OMe-m7GpppAmpG ammonium		≥99.0%
3'OMe-m7GpppAmpG ammonium is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.

HY-139101A

Guanosine 5'-triphosphate-5'-adenosine triammonium		99.97%
Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium, a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine triammonium is a fluorescent substrate analog.

Guanosine 5′-(tetrahydrogen triphosphate), P′′→5′-ester with adenosine (triammonium) Guanosine 5′-(tetrahydrogen triphosphate), P′′→5′-ester with adenosine (triammonium)

HY-145975A

m7Gpppm6AmpG ammonium		98.84%
m7Gpppm6AmpG ammonium is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG ammonium can be used for RNA synthesis in vitro.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-N-methyl-2′-O-methylguanylyl-(3′→5′)-, inner salt, ammonium Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-N-methyl-2′-O-methylguanylyl-(3′→5′)-, inner salt, ammonium

HY-164188

m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium
m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium is a Cy5-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy5 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-164189

m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium
m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-164190

m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-139100

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine	62828-63-1
N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog that can be used for in vitro RNA transcription.

Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with adenosine Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with adenosine

HY-145969

β-S-ARCA	1093268-63-3
β-S-ARCA is a mRNA 7-methylguanosine (m⁷G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines.

5′-Guanylic acid, 7-methyl-2′-O-methyl-, inner salt, P′-anhydride with 5′-guanylic acid monoanhydride with phosphorothioic acid 5′-Guanylic acid, 7-methyl-2′-O-methyl-, inner salt, P′-anhydride with 5′-guanylic acid monoanhydride with phosphorothioic acid

HY-145979

m7GpppUmpG	2638447-87-5
m7GpppUmpG, an oligonucleotide, is an M⁷GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.

m7GpppUmpG m7GpppUmpG

HY-139098

7-Methyl-diguanosine triphosphate	62828-64-2
7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that can incorporated into mRNA. 7-Methyl-diguanosine triphosphate is involved in translation and mRNA degradation in mammalian cells.

Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with guanosine Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with guanosine

HY-145975

m7Gpppm6AmpG	71340-22-2
m7Gpppm6AmpG is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG can be used for RNA synthesis in vitro.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-N-methyl-2′-O-methylguanylyl-(3′→5′)-, inner salt Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-N-methyl-2′-O-methylguanylyl-(3′→5′)-, inner salt

HY-145977

m7GpppGmpG	1258049-00-1
m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylguanylyl-(3′→5′)-, inner salt Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylguanylyl-(3′→5′)-, inner salt

HY-145977A

m7GpppGmpG ammonium
m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylguanylyl-(3′→5′)-, inner salt, ammonium Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylguanylyl-(3′→5′)-, inner salt, ammonium

HY-145980

m7GpppUpG	2638447-85-3
m7GpppUpG, an oligonucleotide, is an M⁷GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.

m7GpppUpG m7GpppUpG

HY-145981

m7GpppCpG	2638447-78-4
m7GpppCpG, an oligonucleotide, is an M⁷GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.

m7GpppCpG m7GpppCpG

HY-145982

m7GpppCmpG	2089461-56-1
m7GpppCmpG, an oligonucleotide, is an M⁷GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.

Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylcytidylyl-(3′→5′)-, inner salt Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5′→5′)-2′-O-methylcytidylyl-(3′→5′)-, inner salt

HY-147339

M7G(3'-OMe-5')pppA(2'-OMe)
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.

2-Amino-9-((2R,3S,4R,5R)-5-((((((((((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)-7-methyl-9H-purin-7-ium-6-olate 2-Amino-9-((2R,3S,4R,5R)-5-((((((((((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)-7-methyl-9H-purin-7-ium-6-olate

HY-150144

Uracil-m7GpppAmpG ammonium
Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

2-Amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium, ammonia salt 2-Amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium, ammonia salt

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