2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. OM-1700

OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM).

For research use only. We do not sell to patients.

OM-1700 Chemical Structure

OM-1700 Chemical Structure

CAS No. : 2406276-78-4

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OM-1700 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • Biological Activity

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Description

OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].

IC50 & Target[1]

TNKS1

127 nM (IC50)

TNKS2

14 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
COLO 320DM GI50
650 nM
Compound: 1; OM-1700
Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay
Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay
[PMID: 34878777]
COLO 320DM GI50
650 nM
Compound: 13; OM-1700
Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay
Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay
[PMID: 32511917]
HEK293 IC50
19 nM
Compound: 13; OM-1700
Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay
Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay
[PMID: 32511917]
RKO GI50
> 10000 nM
Compound: 1; OM-1700
Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay
Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay
[PMID: 34878777]
In Vitro

OM-153 shows inhibition (IC50=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OM-1700 Related Antibodies
Molecular Weight

458.49

Formula

C25H23FN6O2
CAS No.
SMILES

FC1=[C@](C=CC=C1)[N@]2C([C@]3([H])C[C@H](C3)NC(C4=CC=CC=N4)=O)=NN=C2C5=CC=C(C=N5)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OM-1700 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OM-17002406276-78-4OM1700OM 1700PARPpoly ADP ribose polymeraseTNKS1TNKS2HEK293WNT/β-catenin signalingcell growthcolon cancer cell lineCOLO 320DMInhibitorinhibitorinhibit

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