ONO-AE 248

Cat. No.: HY-12184 Purity: 98.27%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels.

For research use only. We do not sell to patients.

ONO-AE 248 Chemical Structure

CAS No. : 211230-67-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Molecular Weight

380.52

Formula

C₂₂H₃₆O₅

CAS No.

211230-67-0

Appearance

Oil

Color

Colorless to light yellow

SMILES

CCCCC[C@H](OC)/C=C/[C@@H]1[C@H](C(C[C@H]1OC)=O)C/C=C\CCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (262.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6280 mL	13.1399 mL	26.2798 mL
5 mM	0.5256 mL	2.6280 mL	5.2560 mL
10 mM	0.2628 mL	1.3140 mL	2.6280 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) HNMR (259 KB) RP-HPLC (256 KB) LCMS (234 KB)

Handling Instructions (2659 KB)

References

[1]. Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6280 mL	13.1399 mL	26.2798 mL	65.6996 mL
	5 mM	0.5256 mL	2.6280 mL	5.2560 mL	13.1399 mL
	10 mM	0.2628 mL	1.3140 mL	2.6280 mL	6.5700 mL
	15 mM	0.1752 mL	0.8760 mL	1.7520 mL	4.3800 mL
	20 mM	0.1314 mL	0.6570 mL	1.3140 mL	3.2850 mL
	25 mM	0.1051 mL	0.5256 mL	1.0512 mL	2.6280 mL
	30 mM	0.0876 mL	0.4380 mL	0.8760 mL	2.1900 mL
	40 mM	0.0657 mL	0.3285 mL	0.6570 mL	1.6425 mL
	50 mM	0.0526 mL	0.2628 mL	0.5256 mL	1.3140 mL
	60 mM	0.0438 mL	0.2190 mL	0.4380 mL	1.0950 mL
	80 mM	0.0328 mL	0.1642 mL	0.3285 mL	0.8212 mL
	100 mM	0.0263 mL	0.1314 mL	0.2628 mL	0.6570 mL

ONO-AE 248 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-AE 248211230-67-0Prostaglandin ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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ONO-AE 248

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