ORC-13661 hydrochloride 

ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker^[1].

ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs)^[1].
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394)^[1].
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ORC-13661 (0.2-5 mg/kg; p.o.; daily, for 10 d) hydrochloride protects hearing from amikacin in rats in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

427.35

C₁₈H₂₀Cl₂N₄O₂S

1979935-34-6

NC(C1=C(NC(NC2=CC=C(C=C2)Cl)=O)SC3=C1[C@](CC4)([H])N(C)[C@]4([H])C3)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kitcher SR, et, al. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.  [Content Brief]