2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Orellanine

Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC).

For research use only. We do not sell to patients.

Orellanine Chemical Structure

Orellanine Chemical Structure

CAS No. : 37338-80-0

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Description

Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2].

Clinical Trial
Molecular Weight

252.18

Formula

C10H8N2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[O-][N+]1=CC=C(O)C(O)=C1C2=C(O)C(O)=CC=[N+]2[O-]
Structure Classification
Initial Source

Cortinarius orellanus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (79.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9654 mL 19.8271 mL 39.6542 mL
5 mM 0.7931 mL 3.9654 mL 7.9308 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9654 mL 19.8271 mL 39.6542 mL 99.1355 mL
5 mM 0.7931 mL 3.9654 mL 7.9308 mL 19.8271 mL
10 mM 0.3965 mL 1.9827 mL 3.9654 mL 9.9136 mL
15 mM 0.2644 mL 1.3218 mL 2.6436 mL 6.6090 mL
20 mM 0.1983 mL 0.9914 mL 1.9827 mL 4.9568 mL
25 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9654 mL
30 mM 0.1322 mL 0.6609 mL 1.3218 mL 3.3045 mL
40 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4784 mL
50 mM 0.0793 mL 0.3965 mL 0.7931 mL 1.9827 mL
60 mM 0.0661 mL 0.3305 mL 0.6609 mL 1.6523 mL
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Orellanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orellanine37338-80-0PhosphataseccRCCcancerproximal tubular cellALPfungal nephrotoxinInhibitorinhibitorinhibit

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