2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. Orotic acid zinc

Orotic acid zinc  (Synonyms: 6-Carboxyuracil zinc; Vitamin B13 zinc)

Cat. No.: HY-N0157A Purity: 99.84%
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Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.

For research use only. We do not sell to patients.

Orotic acid zinc Chemical Structure

Orotic acid zinc Chemical Structure

CAS No. : 68399-76-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Orotic acid zinc:

Orotic acid zinc Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Orotic acid zinc

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  • Purity & Documentation

  • References

  • Customer Review

Description

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Orotic acid zinc Related Antibodies
In Vivo

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

188.79

Formula

C5H4N2O4Zn0.5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(NC1=O)=CC(N1)=O)O.[0.5Zn]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (105.94 mM; ultrasonic and adjust pH to 2 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2969 mL 26.4845 mL 52.9689 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2969 mL 26.4845 mL 52.9689 mL 132.4223 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL 26.4845 mL
10 mM 0.5297 mL 2.6484 mL 5.2969 mL 13.2422 mL
15 mM 0.3531 mL 1.7656 mL 3.5313 mL 8.8282 mL
20 mM 0.2648 mL 1.3242 mL 2.6484 mL 6.6211 mL
25 mM 0.2119 mL 1.0594 mL 2.1188 mL 5.2969 mL
30 mM 0.1766 mL 0.8828 mL 1.7656 mL 4.4141 mL
40 mM 0.1324 mL 0.6621 mL 1.3242 mL 3.3106 mL
50 mM 0.1059 mL 0.5297 mL 1.0594 mL 2.6484 mL
60 mM 0.0883 mL 0.4414 mL 0.8828 mL 2.2070 mL
80 mM 0.0662 mL 0.3311 mL 0.6621 mL 1.6553 mL
100 mM 0.0530 mL 0.2648 mL 0.5297 mL 1.3242 mL
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Orotic acid zinc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orotic acid68399-76-86-CarboxyuracilVitamin B13Vitamin B 13Vitamin B-13Nucleoside Antimetabolite/AnalogEndogenous MetabolitepyrimidinenucleotidesRNAureahepaticsteatosishepatomegalyInhibitorinhibitorinhibit

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