1. Vitamin D Related/Nuclear Receptor
  2. Thyroid Hormone Receptor
  3. Orotirelin

Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases.

For research use only. We do not sell to patients.

Orotirelin Chemical Structure

Orotirelin Chemical Structure

CAS No. : 62305-86-6

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Description

Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases[1].

In Vivo

In the pentobarbitone anaesthetized rats, Bilateral injection of Orotirelin (0.1-1.0 μg) into the nucleus accumbens reduced the Pentobarbitone-induced sleeping time[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (270-290 g) anaesthetized with Sodium Pentobarbitone (60mg/kg, i.p.)[1]
Dosage: 0.1-1.0 μg (0.5 μL each side)
Administration: Intracerebral injection; once
Result: Reversed the Pentobarbitone-induced sleeping time.
Molecular Weight

389.37

Formula

C16H19N7O5

CAS No.
SMILES

O=C([C@H]1N(CCC1)C([C@@H](NC(C(NC2=O)=CC(N2)=O)=O)CC3=CNC=N3)=O)N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Orotirelin
Cat. No.:
HY-122353
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