2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. OTS447

OTS447 is a potent FLT3 inhibitor with an IC50 of 21 nM (WO2012016082A1, compound 335).

For research use only. We do not sell to patients.

OTS447 Chemical Structure

OTS447 Chemical Structure

CAS No. : 1356943-67-3

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Based on 1 publication(s) in Google Scholar

OTS447 Related Antibodies

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Description

OTS447 is a potent FLT3 inhibitor with an IC50 of 21 nM (WO2012016082A1, compound 335)[1].

Molecular Weight

466.01

Formula

C27H32ClN3O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=C(NC2CCC(N(CC)CC)CC2)C3=CC(C4=CC=C(O)C(Cl)=C4)=CC=C3N=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.41 mg/mL (26.63 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1459 mL 10.7294 mL 21.4588 mL
5 mM 0.4292 mL 2.1459 mL 4.2918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.83%

COA (252 KB) HNMR (436 KB) RP-HPLC (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1459 mL 10.7294 mL 21.4588 mL 53.6469 mL
5 mM 0.4292 mL 2.1459 mL 4.2918 mL 10.7294 mL
10 mM 0.2146 mL 1.0729 mL 2.1459 mL 5.3647 mL
15 mM 0.1431 mL 0.7153 mL 1.4306 mL 3.5765 mL
20 mM 0.1073 mL 0.5365 mL 1.0729 mL 2.6823 mL
25 mM 0.0858 mL 0.4292 mL 0.8584 mL 2.1459 mL
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OTS447 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OTS4471356943-67-3OTS 447OTS-447FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3MELKmammalian embryonic developmentbreast cancerInhibitorinhibitorinhibit

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