Oxyphenbutazone monohydrate

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Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis.

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Oxyphenbutazone monohydrate Chemical Structure

CAS No. : 7081-38-1

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Other Forms of Oxyphenbutazone monohydrate:

Oxyphenbutazone Get quote
Oxyphenbutazone (monohydrate) (Standard) Get quote

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•Related Small Molecules:

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

COX, Bacteria^[1]^[2]

In Vitro

Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells^[1].
Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells^[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Hep3B cells
Concentration:	2.5 µM, 5 µM, 7.5 µM
Incubation Time:	48 hours
Result:	Enhanced the cytotoxicity of MTX.

In Vivo

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar strain albino male rats (5-6 weeks; 150-220 g)^[1]
Dosage:	70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration:	PO; once a week; in two divided doses; for 13 weeks
Result:	Exerted potential anticancer activity in rats when co-treatment with MTX.

Molecular Weight

342.39

Formula

C₁₉H₂₂N₂O₄

CAS No.

7081-38-1

SMILES

O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=C(O)C=C3)C1=O.O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196. [Content Brief]

[2]. Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11. [Content Brief]