2. Cell Cycle/DNA Damage
  3. CDK
  4. P162-0948

P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis.

For research use only. We do not sell to patients.

P162-0948 Chemical Structure

P162-0948 Chemical Structure

CAS No. : 1358201-44-1

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P162-0948 Related Antibodies

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Description

P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].

IC50 & Target

CDK8

50.4 nM (IC50)

Molecular Weight

362.36

Formula

C20H15FN4O2
CAS No.
SMILES

FC1=CC=C(CNC(CC2=NN=C(C3=CC=C4C(C=CC=N4)=C3)O2)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P162-0948 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P162-09481358201-44-1CDKCyclin dependent kinaseCDK8A549 human alveolar epithelial cellpulmonary fibrosisInhibitorinhibitorinhibit

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