2. Anti-infection
  3. Fungal
  4. P163-0892

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration.

For research use only. We do not sell to patients.

P163-0892 Chemical Structure

P163-0892 Chemical Structure

CAS No. : 1574576-45-6

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P163-0892 Related Antibodies

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Description

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration[1].

In Vitro

P163-0892 (0-32 μg/mL; 48 h) shows antifungal activity with a MIC of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively[1].
P163-0892 has good aqueous solubility[1].
P163-0892 has no cytotoxicity and no obvious cardiotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P163-0892 Related Antibodies
In Vivo

P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wax moth larva infected with C. neoformans H99 or C. gattii WM178[1]
Dosage: 10 mg/kg
Administration: 5 days
Result: Increased the survival rate of larvae.
Animal Model: Male Sprague–Dawley rats weighing 200–250 g[1]
Dosage: 2 mg/kg or 5 mg/kg
Administration: Intravenous or oral administration (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of P163-0892a[1]
route dose (mg/kg) T1/2 (h) Tmax (h) AUC0-inf (h•ng/mL) Cl (mL/h/kg) MRT0-t (h) Vdss (L/kg) BA (%)
iv 2 mg/kg 7.61 749 172 2.63 7.12
po 5 mg/kg 15.3 3.17 NR 3.83 NR 0.8

aAbbreviations: iv, intravenous; po, per os; T1/2, half-life elimination in hours; Tmax, time of maximal concentration in hours; AUC, area under the curve; Cl, clearance; MRT, mean residence time; Vdss, volume of distribution at the steady state; BA, bioavailability; NR, not reportable; n = 3.
Molecular Weight

356.44

Formula

C19H20N2O3S
CAS No.
SMILES

O=C(C1=C(O)C2=C(C=CS2)N(CC3=CC=CC=C3)C1=O)NCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P163-0892 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P163-08921574576-45-6FungalCryptococcus neoformansCryptococcus gattiihepatotoxicitywax moth larvaInhibitorinhibitorinhibit

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