2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. P2X4 antagonist-2

P2X4 antagonist-2 is an antagonist for P2X4 with an IC50 of 24 nM.

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P2X4 antagonist-2 Chemical Structure

P2X4 antagonist-2 Chemical Structure

CAS No. : 2055601-24-4

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P2X4 antagonist-2 Related Antibodies

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Description

P2X4 antagonist-2 is an antagonist for P2X4 with an IC50 of 24 nM[1].

IC50 & Target

P2X4 Receptor

24 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
24 nM
Compound: 21
Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins and measured every 2 secs for 120 secs by Fluo8-AM staining based FLIPR assay
Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins and measured every 2 secs for 120 secs by Fluo8-AM staining based FLIPR assay
[PMID: 31746599]
Molecular Weight

484.88

Formula

C21H16ClF3N2O4S
CAS No.
SMILES

O=C(CC1=C(C(F)(F)F)C=CC=C1)NC2=CC=C(C(S(=O)(N)=O)=C2)OC3=CC(Cl)=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P2X4 antagonist-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P2X4 antagonist-22055601-24-4P2X ReceptorP2XRsanalgesicsInhibitorinhibitorinhibit

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