2. Apoptosis
  3. MDM-2/p53
  4. p53 Activator 5

p53 Activator 5 (compound 134A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 5 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 5 shows anti-tumor activity. p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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p53 Activator 5 Chemical Structure

p53 Activator 5 Chemical Structure

CAS No. : 2636840-37-2

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1 mg USD 272 In-stock
5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2100 In-stock
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Description

p53 Activator 5 (compound 134A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 5 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 5 shows anti-tumor activity[1]. p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

566.58

Formula

C29H32F6N4O
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

COC1=CC(C(F)(F)F)=CC=C1NCC#CC2=CC3=C(C=CC=C3N[C@@H](CC4)CC[C@H]4N(C)C)N2CC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (176.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7650 mL 8.8249 mL 17.6498 mL
5 mM 0.3530 mL 1.7650 mL 3.5300 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7650 mL 8.8249 mL 17.6498 mL 44.1244 mL
5 mM 0.3530 mL 1.7650 mL 3.5300 mL 8.8249 mL
10 mM 0.1765 mL 0.8825 mL 1.7650 mL 4.4124 mL
15 mM 0.1177 mL 0.5883 mL 1.1767 mL 2.9416 mL
20 mM 0.0882 mL 0.4412 mL 0.8825 mL 2.2062 mL
25 mM 0.0706 mL 0.3530 mL 0.7060 mL 1.7650 mL
30 mM 0.0588 mL 0.2942 mL 0.5883 mL 1.4708 mL
40 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1031 mL
50 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8825 mL
60 mM 0.0294 mL 0.1471 mL 0.2942 mL 0.7354 mL
80 mM 0.0221 mL 0.1103 mL 0.2206 mL 0.5516 mL
100 mM 0.0176 mL 0.0882 mL 0.1765 mL 0.4412 mL
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p53 Activator 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Activator 52636840-37-2MDM-2/p53Inhibitorinhibitorinhibit

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