p53-HDM2-IN-1

Cat. No.: HY-145907: FAQs
Data Sheet Handling Instructions

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p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC₅₀ of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

p53-HDM2-IN-1 Chemical Structure

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Description	p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC₅₀ of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer^[1].
Molecular Weight	772.75
Formula	C₃₅H₃₈F₆N₄O₇S
SMILES	CCC[C@H]1N(CCC[C@@]1(OC2=CSC(C(F)(F)F)=C2)C(N3CCN(CC3)C4=CC=CC=C4OCCCC(O)=O)=O)C(C5=C(C=CN=C5O)C(F)(F)F)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625. [Content Brief]

p53-HDM2-IN-1 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53-HDM2-IN-1MDM-2/p53p53-HDM2PPIcancerInhibitorinhibitorinhibit

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p53-HDM2-IN-1

p53-HDM2-IN-1 Related Antibodies

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