p53-MDM2-IN-3 

p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a K_i value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway^[1].

p53-MDM2-IN-3 (0.1-20 μM, 4 h) dose-dependent increases p65 levels in A549 cytoplasm and nucleus^[1].
p53-MDM2-IN-3 (0.1-10 μM, 4 h) selectively activates p53 or inhibits the NF-κB pathway in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p53-MDM2-IN-3 (200 mg/kg, gavage for 14 days) effectively inhibits tumor growth in A549 xenotransplantation model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

570.45

C₃₀H₂₅BrFN₅O

1542066-74-9

O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=C(C=C6)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhuang C, et al. Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway. J Med Chem. 2014 Feb 13;57(3):567-77.  [Content Brief]