2. Others
  3. Others
  4. PAA4

PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model.

For research use only. We do not sell to patients.

PAA4 Chemical Structure

PAA4 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PAA4 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model[1].

In Vitro

PAA4 (0-4 µM; 24 h) shows no significant cytotoxicity in EJ, HUVEC, SV-HUC-1 cell lines with IC50 values of 2.1, 0.80, 2.3 µM, respectively[1].
PAA4 (4 µM; 1, 3, 6 h) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAA4 Related Antibodies

Cell Viability Assay[1]

Cell Line: HUVEC, EJ, SV-HUC-1 cells
Concentration: 0, 0.5, 1, 1.5, 2, 4 µM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity in EJ, HUVEC, SV-HUC-1 cell lines with IC50 values of 2.1, 0.80, 2.3 µM, respectively.

Western Blot Analysis[1]

Cell Line: EJ cells
Concentration: 4 µM
Incubation Time: 1, 3, 6 h
Result: Increased the expression of pH2AX in a time dependent manner.
In Vivo

PAA4 (1.5 µM, 100 µL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, 18 g, female BALB/c nude mice[1]
Dosage: 1.5 µM, 100 µL
Administration: Intravesical delivered into the bladder; 5 times every other day for 8 days
Result: Exhibited a good anti-tumor effect with the small average tumor volume of 564 ± 180 mm3 after 22 days and no significant body weight loss.
Molecular Weight

1064.89

Formula

C14H8Au4BF4N
SMILES

[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au]5[Au]2[Au]3[Au]45)=NC6=C7C=CC=C6)=C7C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PAA4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAA4PAA 4PAA-4OthersantiproliferativeEJ cellspH2AXanti-tumororthotopic bladder cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PAA4
Cat. No.:
HY-149035
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.