2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Ferroptosis Endogenous Metabolite Reactive Oxygen Species
  4. PAA5

PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity.

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PAA5 Chemical Structure

PAA5 Chemical Structure

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PAA5 Related Antibodies

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Description

PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity[1].

In Vitro

PAA5 (0-4 µM; 24 h) induces ferroptosis and increase of the ferroptosis marker gene prostaglandin-endoperoxide synthase 2 (PTGS2). PAA5 decreases cell viability in EJ cells with IC50 values of 1.0 µM and 2.7 µM for EJ and HUVEC cells, respectively[1].
PAA5 (1.5 μM; 4 h; EJ and HUVEC cells) releases active Au(I) metabolites within cells and increases GSH and ROS level[1].
PAA5 (4 µM; 1, 3 and 6 h, EJ cells) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAA5 Related Antibodies

Cell Viability Assay[1]

Cell Line: HUVEC, EJ cells
Concentration: 0, 0.5, 1, 1.5, 2, and 4 µM
Incubation Time: 24 hours
Result: Decreased cell viability of EJ cells 57 and 55%, respectively, compare with HUVEC cells.

Western Blot Analysis[1]

Cell Line: EJ cells
Concentration: 4 µM
Incubation Time: 1, 3, and 6 hours
Result: Increased the expression of pH2AX in a time dependent manner.
In Vivo

PAA5 (1.5 µM, 100 µL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, 18 g, female BALB/c nude mice[1]
Dosage: 1.5 µM, 100 µL
Administration: Intravesical delivered into the bladder; 5 times every other day for 8 days
Result: Exhibited a good antitumor effect with the small average tumor volume of 564 ± 180 mm3 after 22 days and no significant body weight loss.
Molecular Weight

1348.66

Formula

C14H8Au5B2F8N2-
SMILES

[F-][B+3]([F-])([F-])[F-].[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au@@]56[Au@]27[Au]358[Au]46)=[N]([Au]78)C9=C%10C=CC=C9)=C%10C=CC=C1.[2+]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAA5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAA5PAA 5PAA-5FerroptosisEndogenous MetaboliteReactive Oxygen SpeciesantiproliferativeEJ cellspH2AXanti-tumororthotopic bladder cancerInhibitorinhibitorinhibit

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