2. Epigenetics
  3. Protein Arginine Deiminase
  4. PAD4-IN-2

PAD4-IN-2 (compound 5i) is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils.

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PAD4-IN-2 Chemical Structure

PAD4-IN-2 Chemical Structure

CAS No. : 2642327-52-2

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Description

PAD4-IN-2 (compound 5i) is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils[1].

IC50 & Target

IC50: 1.94 μM (PAD4)[1].
Molecular Weight

503.70

Formula

C20H23BClN7O6
CAS No.
SMILES

O=C(NCC1=CC=CC(B(O)O)=C1)[C@H](CCCNC(CCl)=N)NC2=CC=C([N+]([O-])=O)C3=NON=C32
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAD4-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAD4-IN-22642327-52-2Protein Arginine DeiminasePeptidylarginine DeiminasePAD4-H3cit-NETstumorcancerInhibitorinhibitorinhibit

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