PAMP-12(human, porcine)

Name: PAMP-12(human, porcine)
Brand: MedChemExpress
SKU: HY-P2198
Rating: 4.5 (1 reviews)

Cat. No.: HY-P2198 Purity: 97.27%: FAQs
Data Sheet SDS COA Handling Instructions

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PAMP-12(human, porcine) is a major component of immunoreactive (ir)-PAMP, is processed from the adrenomedullin precursor, is a potent hypotensive peptide and participates in cardiovascular control.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PAMP-12(human, porcine) Chemical Structure

CAS No. : 196305-05-2

Size	Price	Stock	Quantity
1 mg	USD 132	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 396	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PAMP-12(human, porcine):

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PAMP-12(human, porcine) is a major component of immunoreactive (ir)-PAMP, is processed from the adrenomedullin precursor, is a potent hypotensive peptide and participates in cardiovascular control^[1].

In Vitro

PAMP-12 (human, porcine) is the PAMP[9-20] with a C-terminal amide structure. Intravenous injections of PAMP-12 in anesthetized rats show a significant hypotensive effect in a dose-dependent fashion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1618.93

Formula

C₇₇H₁₁₉N₂₅O₁₄

CAS No.

196305-05-2

Appearance

Solid

Color

White to off-white

Sequence Shortening

FRKKWNKWALSR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Purity: 97.27%

Select Batch:

Data Sheet (257 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (214 KB)

Handling Instructions (2659 KB)

References

[1]. K Kuwasako, et al. Purification and Characterization of PAMP-12 (PAMP[9-20]) in Porcine Adrenal Medulla as a Major Endogenous Biologically Active Peptide. FEBS Lett. 1997 Sep 1;414(1):105-10. [Content Brief]