2. Anti-infection
  3. Influenza Virus
  4. PAN endonuclease-IN-1

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target.

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PAN endonuclease-IN-1 Chemical Structure

PAN endonuclease-IN-1 Chemical Structure

CAS No. : 2378640-67-4

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PAN endonuclease-IN-1 Related Antibodies

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Description

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].

IC50 & Target

Kd: 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases[1].
Cellular Effect
Cell Line Type Value Description References
MDCK CC50
> 800 μM
Compound: 23
Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
[PMID: 31536340]
NIH3T3 CC50
> 800 μM
Compound: 23
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
[PMID: 31536340]
Molecular Weight

367.24

Formula

C14H8F3N5O4
CAS No.
SMILES

O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAN endonuclease-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAN endonuclease-IN-12378640-67-4Influenza Virusinfluenzaviral replicationantiviralInhibitorinhibitorinhibit

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