PAN endonuclease-IN-2 

PAN endonuclease-IN-2 (compound T-31) is a PA_N endonuclease inhibitor (IC₅₀: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication^[1].

IC50: 0.15 μM (PA_N endonuclease)[1]

PAN endonuclease-IN-2 (compound T-31) exerts an in vitro anti-influenza EC50 of 0.96 μM against influenza virus A (H1N1/A/WSN/33) in MDCK cells; against other PR/8 (H1N1), The EC50 of H3N2, H5N1, H9N2, and Flu B are 4.76 μM, 1.85 μM, 5.06 μM, 0.71 μM, and 2.36 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

607.24

C₂₅H₂₁Br₂NO₇

O=C([C@H]1N(C(CCC2=CC=C(O)C(O)=C2)=O)CC3=C(C=C(O)C(O)=C3)C1)OC4=C(Br)C=CC=C4Br

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ruan J, et al. Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics. Bioorg Chem. 2024 Mar;144:107139.  [Content Brief]