2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. pan-HER-IN-1

pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities.

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pan-HER-IN-1 Chemical Structure

pan-HER-IN-1 Chemical Structure

CAS No. : 1639040-94-0

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pan-HER-IN-1 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].

IC50 & Target

EGFR

0.38 nM (IC50)

HER4

1.6 nM (IC50)

EGFRL858R/T790M/C797S

2.2 nM (IC50)

HER2

3.5 nM (IC50)

Molecular Weight

408.25

Formula

C19H14BrN5O
CAS No.
SMILES

C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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pan-HER-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pan-HER-IN-11639040-94-0EGFRApoptosisEpidermal growth factor receptorErbB-1HER1H1975antitumororally activeirreversibleInhibitorinhibitorinhibit

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