2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. pan-KRAS-IN-6

pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC50 values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V).

For research use only. We do not sell to patients.

pan-KRAS-IN-6 Chemical Structure

pan-KRAS-IN-6 Chemical Structure

CAS No. : 3033565-36-2

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pan-KRAS-IN-6 Related Antibodies

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Description

pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC50 values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V)[1].

IC50 & Target[1]

KRas G12D

9.79 nM (IC50)

KRas G12V

6.03 nM (IC50)

In Vitro

pan-KRAS-IN-6 (20 nM; 72 h) has a good inhibitory effect on the growth of ASPC-1 cells (IC50=8.8 μm)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

pan-KRAS-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: AsPC-1 and SW480 cell lines
Concentration: 20 nM
Incubation Time: 72 h
Result: Inhibited the growth of AsPC-1 cell lines
Molecular Weight

635.10

Formula

C29H30ClF3N6O3S
CAS No.
SMILES

FC1=C(C2=C(N=C(N)S3)C3=C(F)C=C2)C(Cl)=CC4=C(N5CC(C)(O)COCC5)N=C(OC[C@@]6(CCC7)N7C[C@H](F)C6)N=C14
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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pan-KRAS-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pan-KRAS-IN-63033565-36-2RasAsPC-1 and SW480 cell linespan-KRASpancreatic cancerInhibitorinhibitorinhibit

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