Pancratistatin (Synonyms: (+)-Pancratistatin)

Cat. No.: HY-102010: FAQs
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Pancratistatin is an isoquinoline alkaloid that can be isolated from Hymenocallis littoralis. Pancratistatin induces apoptosis of human melanoma cells. Pancratistatin can be used for the research of neuroblastoma, leukemia and breast cancer.

For research use only. We do not sell to patients.

Pancratistatin Chemical Structure

CAS No. : 96203-70-2

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	0.02 μg/mL Compound: 1a	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 22413911]
BXPC-3	ED₅₀	0.02 μg/mL Compound: 1	Growth inhibition of human BXPC3 cells after 48 hrs Growth inhibition of human BXPC3 cells after 48 hrs	[PMID: 17346078]
BXPC-3	ED₅₀	0.043 μg/mL Compound: 1	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 16124772]
DU-145	GI₅₀	0.015 μg/mL Compound: 1a	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 22413911]
DU-145	GI₅₀	0.015 μg/mL Compound: 1	Growth inhibition of human DU145 cells after 48 hrs Growth inhibition of human DU145 cells after 48 hrs	[PMID: 17346078]
DU-145	ED₅₀	0.037 μg/mL Compound: 1	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 16124772]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1a	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 22413911]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs Growth inhibition of human KM20L2 cells after 48 hrs	[PMID: 17346078]
KM-20L2	ED₅₀	0.048 μg/mL Compound: 1	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 16124772]
MCF7	GI₅₀	0.023 μg/mL Compound: 1a	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22413911]
MCF7	ED₅₀	0.023 μg/mL Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17346078]
MCF7	ED₅₀	0.035 μg/mL Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 16124772]
NCI-H460	ED₅₀	0.029 μg/mL Compound: 1	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 16124772]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1a	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 22413911]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs Growth inhibition of human NCI-H460 cells after 48 hrs	[PMID: 17346078]
P388	ED₅₀	0.017 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells after 48 hrs by cell counting Cytotoxicity against mouse P388 cells after 48 hrs by cell counting	[PMID: 22413911]
P388	ED₅₀	0.017 μg/mL Compound: 1	Growth inhibition of murine P388 cells after 48 hrs Growth inhibition of murine P388 cells after 48 hrs	[PMID: 17346078]
SF-268	GI₅₀	0.014 μg/mL Compound: 1a	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 22413911]
SF-268	GI₅₀	0.014 μg/mL Compound: 1	Growth inhibition of human SF268 cells after 48 hrs Growth inhibition of human SF268 cells after 48 hrs	[PMID: 17346078]
SF-268	ED₅₀	0.032 μg/mL Compound: 1	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 16124772]
Vero	IC₅₀	0.016 μg/mL Compound: 4	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.022 μg/mL Compound: 4	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.063 μg/mL Compound: 4	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.16 μg/mL Compound: 4	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]

Molecular Weight

325.27

Formula

C₁₄H₁₅NO₈

CAS No.

96203-70-2

SMILES

O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@]2([H])C3=C1C(O)=C4C(OCO4)=C3

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chatterjee SJ, et al. Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res. 2011 Feb;21(1):1-11. [Content Brief]

Pancratistatin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pancratistatin96203-70-2(+)-PancratistatinApoptosisalkaloidHymenocallis littoralisapoptosisneuroblastomaleukemiabreast cancerInhibitorinhibitorinhibit

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Pancratistatin (Synonyms: (+)-Pancratistatin)

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Pancratistatin Related Classifications

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The dilution calculator equation

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