2. Cell Cycle/DNA Damage Epigenetics
  3. PARP HDAC
  4. PARP-1/HDAC-IN-1

PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities.

For research use only. We do not sell to patients.

PARP-1/HDAC-IN-1 Chemical Structure

PARP-1/HDAC-IN-1 Chemical Structure

CAS No. : 3032621-10-3

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PARP-1/HDAC-IN-1 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities[1].

IC50 & Target[1]

PARP-1

68.90 nM (IC50)

HDAC6

510 nM (IC50)

HDAC2

42130 nM (IC50)

HDAC3

7220 nM (IC50)

In Vitro

PARP-1/HDAC-IN-1 (Compound 1–8-6) possesses potent inhibitory activity against MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1 cells with IC50 values of 0.35 μM, 1.16 μM, 3.38 μM, 5.67 μM, 2.85 μM, and 4.53 μM, respectively[1].
PARP-1/HDAC-IN-1 (Compound 1–8-6; 0.3-10 μM) is able to heighten expression level of acetylated α-tubulin with marginal effects to acetylated histones H3 and H4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP-1/HDAC-IN-1 Related Antibodies
Molecular Weight

402.40

Formula

C22H18N4O4
CAS No.
SMILES

NC(C1=CC=CC2=CN(N=C21)C3=CC=C(C=C3)OCC4=CC=C(C=C4)C(NO)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PARP-1/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-1/HDAC-IN-13032621-10-3PARPHDACpoly ADP ribose polymerase Histone deacetylasesPARP-1HDAC6anticanceranti-migrationanti-angiogenesis activitiesacetylated α-tubulinInhibitorinhibitorinhibit

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