2. Cell Cycle/DNA Damage Epigenetics
  3. PARP HDAC
  4. PARP/HDAC-IN-1

PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively.

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PARP/HDAC-IN-1 Chemical Structure

PARP/HDAC-IN-1 Chemical Structure

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PARP/HDAC-IN-1 Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively[1].

Molecular Weight

634.67

Formula

C36H32F2N6O3
SMILES

FC(C(C(N1CCN(CC1)CC2=CC=C(C=C2)/C=C/C(NC3=C(C=C(C=C3)F)N)=O)=O)=C4)=CC=C4CC5=NNC(C6=C5C=CC=C6)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PARP/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP/HDAC-IN-1PARPHDACpoly ADP ribose polymerase Histone deacetylasescGAS-STINGtriple-negative breast cancerInhibitorinhibitorinhibit

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