2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP1/2/TNKS1/2-IN-1

PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis.

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PARP1/2/TNKS1/2-IN-1 Chemical Structure

PARP1/2/TNKS1/2-IN-1 Chemical Structure

CAS No. : 2243453-32-7

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PARP1/2/TNKS1/2-IN-1 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis[1].

IC50 & Target

PARP-1

0.25 nM (IC50)

PARP-2

1.2 nM (IC50)

TNKS2

4.15 nM (IC50)

TNKS1

13.5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
AML12 CC50
117.47 μM
Compound: I-9
Cytotoxicity against mouse AML12 cells assessed as reduction in cell viability incubated for 7 days by MTT assay
Cytotoxicity against mouse AML12 cells assessed as reduction in cell viability incubated for 7 days by MTT assay
[PMID: 35504210]
HCT-116 IC50
0.75 μM
Compound: I-9
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
[PMID: 35504210]
MDA-MB-231 IC50
0.87 μM
Compound: I-9
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
[PMID: 35504210]
MDA-MB-468 IC50
0.09 μM
Compound: I-9
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
[PMID: 35504210]
Molecular Weight

634.66

Formula

C35H31FN6O5
CAS No.
SMILES

O=C(N1CCN(C(C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)=O)CC1)NC5=CC=C(C(NC6=CC=C(OC)C=C6)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PARP1/2/TNKS1/2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1/2/TNKS1/2-IN-12243453-32-7PARPApoptosispoly ADP ribose polymerase PARP-1/2TNKS1/2antitumor effectInhibitorinhibitorinhibit

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