2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP1-IN-14

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM.

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PARP1-IN-14 Chemical Structure

PARP1-IN-14 Chemical Structure

CAS No. : 2098639-70-2

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PARP1-IN-14 Related Antibodies

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Description

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].

IC50 & Target

PARP1

0.6 ± 0.1 nM (IC50)

In Vitro

PARP1-IN-14 (compound 19k) significantly inhibited proliferation of resistant Capan-1 cells (IC50s < 0.3 nM)[1].
PARP1-IN-14 (0-1 μM, 24 h) induces DNA damage in parental Capan-1 (BRCA2−/−) and resistant Capan-1 cells[1].
PARP1-IN-14 (0-1 μM, 0-48 h) induces cell cycle arrest and apoptosis in parental and resistant cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP1-IN-14 Related Antibodies
Molecular Weight

525.53

Formula

C28H24FN7O3
CAS No.
SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NN=C(C5=NC(OC)=CC=C5)N4C(C)C3)=O)=C2)C6=C1C=CC=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PARP1-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-142098639-70-2PARPApoptosispoly ADP ribose polymerase Capan-1MDA-MB-436Inhibitorinhibitorinhibit

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