PARP1-IN-14

Cat. No.: HY-155766: FAQs
Data Sheet Handling Instructions

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PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC₅₀ of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1^−/−) and Capan-1 (BRCA2^−/−) cells with IC₅₀ values below 0.3 nM.

For research use only. We do not sell to patients.

PARP1-IN-14 Chemical Structure

CAS No. : 2098639-70-2

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PARP1

0.6 ± 0.1 nM (IC₅₀)

In Vitro

PARP1-IN-14 (compound 19k) significantly inhibited proliferation of resistant Capan-1 cells (IC₅₀s < 0.3 nM)^[1].
PARP1-IN-14 (0-1 μM, 24 h) induces DNA damage in parental Capan-1 (BRCA2^−/−) and resistant Capan-1 cells^[1].
PARP1-IN-14 (0-1 μM, 0-48 h) induces cell cycle arrest and apoptosis in parental and resistant cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

525.53

Formula

C₂₈H₂₄FN₇O₃

CAS No.

2098639-70-2

SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NN=C(C5=NC(OC)=CC=C5)N4C(C)C3)=O)=C2)C6=C1C=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709. [Content Brief]

PARP1-IN-14 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-142098639-70-2PARPApoptosispoly ADP ribose polymerase Capan-1MDA-MB-436Inhibitorinhibitorinhibit

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