PARP1-IN-6

Cat. No.: HY-139879: FAQs
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PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC₅₀ values of 0.94 and 0.48 μM, respectively.

For research use only. We do not sell to patients.

PARP1-IN-6 Chemical Structure

CAS No. : 1654735-36-0

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

Biological Activity
Purity & Documentation
References
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Description

PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC₅₀ values of 0.94 and 0.48 μM, respectively.

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-27	IC₅₀	16 μM Compound: DKD-NIPERA-3g	Cytotoxicity against human CAL-27 cells assessed as reduction in cell viability incubated for 24 hrs by alamar blue assay Cytotoxicity against human CAL-27 cells assessed as reduction in cell viability incubated for 24 hrs by alamar blue assay	[PMID: 36796126]
HeLa	IC₅₀	1.5 μM Compound: TP-3	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34670362]
HepG2	IC₅₀	0.9 μM Compound: TP-3	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34670362]
MCF-10A	IC₅₀	> 10 μM Compound: TP-3	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34670362]
SK-OV-3	IC₅₀	1.7 μM Compound: TP-3	Cytotoxicity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34670362]

Molecular Weight

266.27

Formula

C₁₆H₁₁FN₂O

CAS No.

1654735-36-0

SMILES

O=C1C2=CC=CC=C2N=C(/C=C/C3=CC(F)=CC=C3)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zheng L, et al. Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation. J Med Chem. 2021 Nov 11;64(21):15702-15715. [Content Brief]

PARP1-IN-6 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-61654735-36-0PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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