2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARPYnD

PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells.

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PARPYnD Chemical Structure

PARPYnD Chemical Structure

CAS No. : 2561483-27-8

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Based on 1 publication(s) in Google Scholar

PARPYnD Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells[1].

IC50 & Target

PARP1

 

PARP2

 

Molecular Weight

613.67

Formula

C34H31N9O3
CAS No.
SMILES

N#CC1=CC(NC(CCC2(CCC#C)N=N2)=O)=CN=C1N3CCN(CC3)C(C4=CC=CC(CC5=NNC(C6=C5C=CC=C6)=O)=C4)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PARPYnD Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARPYnD2561483-27-8PARPpoly ADP ribose polymeraseBreast cancerphotoaffinity probeAfBPmultipolar spindleInhibitorinhibitorinhibit

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