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  4. Parsatuzumab

Parsatuzumab  (Synonyms: Anti-EGFL7; RG 7414)

Cat. No.: HY-P99215 Purity: 96.52%
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Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition.

For research use only. We do not sell to patients.

CAS No. : 1312797-14-0

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Based on 1 publication(s) in Google Scholar

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Description

Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

VEGF; EGFL7[1]
In Vitro

EGFL7 is a vascular-restricted extracellular matrix protein that promotes endothelial cell adhesion and survival[1].
Parsatuzumab (48 h) inhibits cell proliferation and increases apoptosis against patient-derived xenograft (PDX) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parsatuzumab Related Antibodies

Cell Viability Assay[2]

Cell Line: Patient-derived xenograft (PDX) cells
Concentration: /
Incubation Time: 48 hours
Result: Inhibited cell proliferation by 70% from 20%, and resulted in apoptosis increases by 67-87% from 8-17%.
In Vivo

Parsatuzumab (anti-EGFL7) enhances the antiangiogenesis, tumor growth control, and survival associated with antiVEGF monotherapy in several xenograft and genetically engineered murine tumor models[1].
Parsatuzumab (50 mg/kg; i.v.; 3 times per week) targets EGFL7 and inhibits mantle cell lymphoma (MCL) cell growth and prolongs survival in mouse models of MCL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice injected with Rec1 cells (s.c.)[2]
Dosage: 50 mg/kg
Administration: Intravenous injection; 3 times per week; sacrificed mice when tumor reached end point criteria
Result: Significantly decreased tumor volume than IgG and increased survival of mice.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Parsatuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Parsatuzumab1312797-14-0Anti-EGFL7 RG 7414RG7414RG 7414RG-7414VEGFRVascular endothelial growth factor receptormetastatic colorectal cancernonsquamous non-small cell lung cancermantle cell lymphomapatient-derived xenograft cellsPDXvascular endothelial growth factorVEGFInhibitorinhibitorinhibit

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