PBB3 

PBB3 is a tracer of tau PET. PBB3 can be used to detect levels of tau protein in Alzheimer's disease and non-Alzheimer's disease^[1].

PBB3 (56.5 µM) labels Alzheimer's disease patient-originated brain pathological changes by fluorescent labeling^[1].
PBB3 (56.5 µM) labels neuropil threads and plaque neurites in hippocampal derived from an Alzheimer’s disease patient^[1].
PBB3 bound to primitive plaques, which is accumulation ofabnormally swollen neurites without cores of extracellular amyloid^[1].
PBB3 clearly detects dystrophic neurites in brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification characterized by accumulation of all six tau isoforms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

309.39

C₁₇H₁₅N₃OS

1565796-97-5

Solid

Yellow to orange

OC1=CC=C2N=C(SC2=C1)/C=C/C=C/C3=CN=C(C=C3)NC

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Maiko Ono, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain. 2017 Mar 1;140(3):764-780.  [Content Brief]