PC Alkyne-PEG4-NHS ester

Name: PC Alkyne-PEG4-NHS ester
Brand: MedChemExpress
SKU: HY-140139
Rating: 4.5 (1 reviews)

Cat. No.: HY-140139 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

PC Alkyne-PEG4-NHS ester Chemical Structure

CAS No. : 1802907-98-7

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Proteins:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

653.63

Formula

C₂₉H₃₉N₃O₁₄

CAS No.

1802907-98-7

Appearance

Viscous Liquid

Color

Light yellow to yellow

SMILES

O=C(OC(C1=CC(OC)=C(OCCCC(NCCOCCOCCOCCOCC#C)=O)C=C1[N+]([O-])=O)C)ON2C(CCC2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (152.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5299 mL	7.6496 mL	15.2992 mL
5 mM	0.3060 mL	1.5299 mL	3.0598 mL
10 mM	0.1530 mL	0.7650 mL	1.5299 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) HNMR (114 KB) LCMS (247 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5299 mL	7.6496 mL	15.2992 mL	38.2479 mL
	5 mM	0.3060 mL	1.5299 mL	3.0598 mL	7.6496 mL
	10 mM	0.1530 mL	0.7650 mL	1.5299 mL	3.8248 mL
	15 mM	0.1020 mL	0.5100 mL	1.0199 mL	2.5499 mL
	20 mM	0.0765 mL	0.3825 mL	0.7650 mL	1.9124 mL
	25 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5299 mL
	30 mM	0.0510 mL	0.2550 mL	0.5100 mL	1.2749 mL
	40 mM	0.0382 mL	0.1912 mL	0.3825 mL	0.9562 mL
	50 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7650 mL
	60 mM	0.0255 mL	0.1275 mL	0.2550 mL	0.6375 mL
	80 mM	0.0191 mL	0.0956 mL	0.1912 mL	0.4781 mL
	100 mM	0.0153 mL	0.0765 mL	0.1530 mL	0.3825 mL