2. Metabolic Enzyme/Protease
  3. PCSK9
  4. PCSK9 modulator-2

PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-2 has the potential for the research of hyperlipidemia.

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PCSK9 modulator-2 Chemical Structure

PCSK9 modulator-2 Chemical Structure

CAS No. : 2365416-53-9

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PCSK9 modulator-2 Related Antibodies

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Description

PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-2 has the potential for the research of hyperlipidemia[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
201.7 nM
Compound: 16
Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
[PMID: 31227343]
Molecular Weight

282.29

Formula

C17H12F2N2
CAS No.
SMILES

FC1=CC=CC2=C1NC=C2CC3=CC4=CC(F)=CC=C4N3
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Purity & Documentation
References
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PCSK9 modulator-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCSK9 modulator-22365416-53-9PCSK9Proprotein convertase subtilisin/kexin type 9LDL-ChyperlipidemiaInhibitorinhibitorinhibit

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PCSK9 modulator-2
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