PD-1/PD-L1 antagonist 1 

PD-1/PD-L1 antagonist 1 (Compound A5) is an antagonist for programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) interaction, with an IC₅₀ of 23.78 nM^[1].

23.78 nM (PD-1/PD-L1 interaction)

PD-1/PD-L1 antagonist 1 (0-3 μM) dose-dependently inhibits PD-1 and PD-L1 interaction in a co-system of Jurkat-NFAT-PD-1 cells and Hep3B-OS8-hPD-L1 cells, exhibits no significant cytotoxicity in Jurkat cells with a safe dose of 3.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

955.88

C₅₂H₄₈Cl₂N₆O₈

ClC(C=C1CNC[C@H](CO)O)=C(C=C1OCC2=CC(C#N)=CC=C2)OCC3=CC=CC(C4=CC=CC5=C4N=CN=C5OC6=CC(OCC7=CC=CC(C#N)=C7)=C(C=C6Cl)CNC[C@H](CO)O)=C3C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu X, et al. Design, Synthesis, and Evaluation of 8-(o-Tolyl) quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists[J]. ACS Medicinal Chemistry Letters, 2024.