1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25 (compound D2) is an inhibitor of PD-1/PD-L1 interaction with an IC50 value of 16.17 nM. PD-1/PD-L1-IN-25 activates the antitumor immunity of T cells efficiently in PBMCs. PD-1/PD-L1-IN-25 can be used for the research of cancer.

For research use only. We do not sell to patients.

PD-1/PD-L1-IN-25 Chemical Structure

PD-1/PD-L1-IN-25 Chemical Structure

CAS No. : 2768759-52-8

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Description

PD-1/PD-L1-IN-25 (compound D2) is an inhibitor of PD-1/PD-L1 interaction with an IC50 value of 16.17 nM. PD-1/PD-L1-IN-25 activates the antitumor immunity of T cells efficiently in PBMCs. PD-1/PD-L1-IN-25 can be used for the research of cancer[1].

IC50 & Target

IC50: 16.17 nM (PD-1/PD-L1)[1].

In Vitro

PD-1/PD-L1-IN-25 (0-1 μM; 90 min) inhibits PD-1/PD-L1 interaction with an IC50 value of 16.17 nM[1].
PD-1/PD-L1-IN-25 (0-2 μM; 2 h) activates the antitumor immunity of T cells efficiently in PBMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB 231 cells by human PBMCs
Concentration: 0-2 μM
Incubation Time: 2 hours
Result: Showed no toxicity towards MDA-MB 231 cells, and activated the antitumor immunity of PBMCs to kill MDA-MB 231 cells efficiently at a concentration of 1.0 μM.
Molecular Weight

493.94

Formula

C26H24ClN3O5

CAS No.
SMILES

O=C(C1=C(C(C2=CC3=C(OCCO3)C=C2)=CC=C1)Cl)NC4=NC=C(C=C4)CN5CC[C@@H](C5)C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PD-1/PD-L1-IN-25
Cat. No.:
HY-143305
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