2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-43

PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies.

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PD-1/PD-L1-IN-43 Chemical Structure

PD-1/PD-L1-IN-43 Chemical Structure

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PD-1/PD-L1-IN-43 Related Antibodies

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Description

PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies[1].
In Vitro

PD-1/PD-L1-IN-43 (0 - 20 μM; 48 h) can reactivate immunosuppressed Jurkat T cells to kill HepG2 cells in the cell co-culture system[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1-IN-43 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2/Jurkat co-culture cell model
Concentration: 0 - 20 μM
Incubation Time: 48 h
Result: Reduced the survival rate of HepG2 cells to 55.16% compared to the control group.
In Vivo

PD-1/PD-L1-IN-43 (20 and 40 mg/kg; i.p.; everday for 2 weeks) inhibits potently tumor growth in vivo by activating the tumor immune microenvironment in C57BL/6J male mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse model of B16-F10 melanoma
Dosage: 20 and 40 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: The tumor growth inhibition values (TGI) of the treatment groups were 42.4 % and 52.6 % at doses of 20 and 40 mg/kg.
Molecular Weight

455.51

Formula

C27H25N3O4
SMILES

O=C(N1N=CC2=C1C=CC=C2C3=CC=C4OCCOC4=C3)C5=CC=C(C=C5)CN6CC[C@H](C6)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-1/PD-L1-IN-43 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-43PD-1/PD-L1PD-1/Programmed death-ligand 1HepG2 cellsB16-F10 melanoma mouse modelPD-1/PD-L1 inhibitortumor immunologyInhibitorinhibitorinhibit

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