2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model.

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PD-1/PD-L1-IN 6 Chemical Structure

PD-1/PD-L1-IN 6 Chemical Structure

CAS No. : 2393983-76-9

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PD-1/PD-L1-IN 6 Related Antibodies

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Description

PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].

IC50 & Target

IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)
Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
38.6 μM
Compound: 1
Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay
[PMID: 33938739]
Jurkat EC50
44.7 μM
Compound: A13
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay
[PMID: 31734021]
T-cell EC50
0.41 μM
Compound: 1
Prevention of antiCD3 antibody/PD-L1-repressed mouse T cell proliferation incubated for 72 hrs by flow cytometry
Prevention of antiCD3 antibody/PD-L1-repressed mouse T cell proliferation incubated for 72 hrs by flow cytometry
[PMID: 33938739]
Molecular Weight

402.49

Formula

C25H26N2O3
CAS No.
SMILES

O=C(C1=CC=C(CNCCO)C(OC)=C1)N2CCC3=C2C=CC=C3C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-1/PD-L1-IN 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN 62393983-76-9PD-1/PD-L1PD-1/Programmed death-ligand 1tumor immunotherapyPD-1/PD-L1 interactionLow toxicityIFN-γ secretionCD3 T cellInhibitorinhibitorinhibit

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