2. GPCR/G Protein
  3. Endothelin Receptor
  4. PD-156707

PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist.

For research use only. We do not sell to patients.

PD-156707 Chemical Structure

PD-156707 Chemical Structure

CAS No. : 162412-70-6

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Based on 1 publication(s) in Google Scholar

PD-156707 Related Antibodies

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Description

PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist[1].

In Vitro

PD-156707 binds to human ETA receptors with an approximately 800-fold higher affinity than to human ETB receptors[1].
PD-156707 inhibits functional responses to ET-1, including inositol phosphate production in Ltk cells expressing recombinant human ETA receptors (IC50 = 2.4 nM) and arachidonic acid release in rabbit renal artery VSMC cells (IC50 = 1.1 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD-156707 Related Antibodies
Molecular Weight

528.48

Formula

C28H25NaO9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(/C(C1=CC=C2OCOC2=C1)=C(C(C3=CC=C(C=C3)OC)=O)/CC4=CC(OC)=C(C(OC)=C4)OC)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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PD-156707 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-156707162412-70-6PD156707PD 156707Endothelin ReceptorET-1ETA receptorvasoconstrictorInhibitorinhibitorinhibit

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HY-123744
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