2. Immunology/Inflammation Epigenetics Cell Cycle/DNA Damage
  3. PD-1/PD-L1 HDAC
  4. PD-L1/HDAC-IN-1

PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME.

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PD-L1/HDAC-IN-1 Chemical Structure

PD-L1/HDAC-IN-1 Chemical Structure

CAS No. : 2923313-69-1

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PD-L1/HDAC-IN-1 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME[1].

IC50 & Target

HDAC3

14.47 nM (IC50)

HDAC2

27.98 nM (IC50)

PD-1/PD-L1

88.10 nM (IC50)

Molecular Weight

740.28

Formula

C42H46ClN3O7
CAS No.
SMILES

N#CC1=CC=CC(COC(C=C(C(Cl)=C2)OCC3=C(C(C4=CC(OCCCCCCC(NO)=O)=CC=C4)=CC=C3)C)=C2CN5[C@H](CCCC5)C(O)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-L1/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1/HDAC-IN-12923313-69-1PD-1/PD-L1HDACPD-1/Programmed death-ligand 1Histone deacetylasesMCF-7HeLaSY5YimmunomodulatoryInhibitorinhibitorinhibit

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