2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-L1-IN-4

PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

PD-L1-IN-4 Chemical Structure

PD-L1-IN-4 Chemical Structure

CAS No. : 2597056-86-3

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PD-L1-IN-4 Related Antibodies

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Description

PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer[1].

In Vitro

PD-L1-IN-4 (0.1-10 μM, 24 h) alleviates the immunosuppressive effect of PD-L1 and reduces cell-surface accessible PD-L1 in PD-L1/aAPC/CHO-K1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD-L1-IN-4 Related Antibodies
In Vivo


Pharmacokinetic Analysis in SD Rat Model[1]

Route Dose (mg/kg) t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng·h/mL)
p.o. 50 5.3 0.1 45.6 82.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

735.20

Formula

C38H40ClFN4O8
CAS No.
SMILES

FC1=C(C=CC=C1C2=CC(OCCCN3CCC(CC3)O)=CC=C2)COC4=CC(OCC5=CC6=NON=C6C=C5)=C(C=C4Cl)CN[C@@H](C(O)=O)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-L1-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1-IN-42597056-86-3PD-1/PD-L1PD-1/Programmed death-ligand 1T cellsPD-L1aAPCCHO-K1SDInhibitorinhibitorinhibit

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