2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-L1/VISTA-IN-1

PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity.

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PD-L1/VISTA-IN-1 Chemical Structure

PD-L1/VISTA-IN-1 Chemical Structure

CAS No. : 2978623-09-3

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PD-L1/VISTA-IN-1 Related Antibodies

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Description

PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity[1].

Molecular Weight

408.45

Formula

C22H24N4O4
CAS No.
SMILES

CC1=C(C=CC=C1C2=CC=CC=C2)NC3=NC(OC)=CC(CN[C@H](C(O)=O)CO)=N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-L1/VISTA-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1/VISTA-IN-12978623-09-3PD-1/PD-L1PD-1/Programmed death-ligand 1A549H1975PBMC293TLung cancer modelInhibitorinhibitorinhibit

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