2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Antifolate Dihydrofolate reductase (DHFR)
  4. PD130883

PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.

For research use only. We do not sell to patients.

PD130883 Chemical Structure

PD130883 Chemical Structure

CAS No. : 123685-36-9

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PD130883 Related Antibodies

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Description

PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.

Molecular Weight

349.34

Formula

C18H15N5O3
CAS No.
SMILES

O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD130883 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD130883123685-36-9PD 130883PD-130883AntifolateDihydrofolate reductase (DHFR)Inhibitorinhibitorinhibit

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