1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. Antifolate Dihydrofolate reductase (DHFR)
  3. PD130883

PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.

For research use only. We do not sell to patients.

PD130883 Chemical Structure

PD130883 Chemical Structure

CAS No. : 123685-36-9

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Description

PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.

Molecular Weight

349.34

Formula

C18H15N5O3

CAS No.
SMILES

O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PD130883
Cat. No.:
HY-118251
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