2. Autophagy Apoptosis
  3. Autophagy Ferroptosis
  4. PD146176 (Standard)

PD146176 (Standard)  (Synonyms: NSC168807 (Standard))

Cat. No.: HY-103157R Purity: ≥98%
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PD146176 (Standard) is the analytical standard of PD146176. This product is intended for research and analytical applications. PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].

For research use only. We do not sell to patients.

PD146176 (Standard) Chemical Structure

PD146176 (Standard) Chemical Structure

CAS No. : 4079-26-9

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Description
Molecular Weight

237.32

Formula

C15H11NS
CAS No.
SMILES

C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PD146176 (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD146176 (Standard)4079-26-9NSC168807 (Standard)AutophagyFerroptosisIC21cellstripletransgenicmicerabbitreticulocytecognitiveimpairmentbrainamyloidosistaupathologyInhibitorinhibitorinhibit

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