2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Phosphodiesterase (PDE) Calcium Channel
  4. PDE1-IN-4

PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.

For research use only. We do not sell to patients.

PDE1-IN-4 Chemical Structure

PDE1-IN-4 Chemical Structure

CAS No. : 3031349-98-8

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PDE1-IN-4 Related Antibodies

Top Publications Citing Use of Products

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research[1].

IC50 & Target

PDE1C

10 ± 3 nM (IC50)

PDE1A

145 nM (IC50)

PDE1B

354 nM (IC50)

PDE4B2

619 nM (IC50)

PDE4D2

948 nM (IC50)

PDE10A

1310 nM (IC50)

PDE5A1

1810 nM (IC50)

PDE2A

5130 nM (IC50)

PDE3A

>10000 nM (IC50)

PDE9A2

>10000 nM (IC50)

In Vitro

PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC50 above 40 μM, indicating that it will not cause cardiotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE1-IN-4 Related Antibodies
Molecular Weight

535.63

Formula

C33H33N3O4
CAS No.
SMILES

CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE1-IN-4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE1-IN-43031349-98-8Phosphodiesterase (PDE)Calcium ChannelCa2+ channelsCa channelsHLF cellsIdiopathic pulmonary fibrosisIPFanti-fibrosisSARS-CoV-2calcium channelInhibitorinhibitorinhibit

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