2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphatase Apoptosis
  4. PDE1-IN-6

PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells.

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PDE1-IN-6 Chemical Structure

PDE1-IN-6 Chemical Structure

CAS No. : 2877017-16-6

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PDE1-IN-6 Related Antibodies

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Description

PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells[1].

In Vitro

PDE1-IN-6 (compound 6c) (10 and 20 μM, 48 h) induces the apoptosis of U937 and ML-1 cells[1].
PDE1-IN-6 (10 and 20 μM, 48 h) decreases the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increases their cleaved caspase-3, 7, 9 in U937 and ML-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE1-IN-6 Related Antibodies

Apoptosis Analysis[1]

Cell Line: U937 and ML-1 cells
Concentration: 10, 20 μM
Incubation Time: 48 h
Result: Induced the apoptosis of U937 and ML-1 cells.

Western Blot Analysis[1]

Cell Line: U937 and ML-1 cells
Concentration: 10, 20 μM
Incubation Time: 48 h
Result: Decreased the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increased their cleaved caspase-3, 7, 9.
Molecular Weight

452.50

Formula

C24H26F2N6O
CAS No.
SMILES

CC(C)(N1N=CC2=C1N=C(N(C2=O)CC3=CC=CC(F)=C3)NCCNC4=CC=C(C=C4)F)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE1-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE1-IN-62877017-16-6PhosphataseApoptosisPhosphodiesterase-1acute myelogenous leukemiaapoptosisInhibitorinhibitorinhibit

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