PDE5/HDAC-IN-1

Cat. No.: HY-147991: FAQs
Data Sheet Handling Instructions

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PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC₅₀ values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities.

For research use only. We do not sell to patients.

PDE5/HDAC-IN-1 Chemical Structure

CAS No. : 2414921-48-3

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•Related Small Molecules:

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View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All HDAC Isoform Specific Products:

View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PDE5

46.3 nM (IC₅₀)

HDAC6

0.11 μM (IC₅₀)

HDAC8

0.12 μM (IC₅₀)

HDAC1

2.45 μM (IC₅₀)

In Vitro

PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC₅₀ values of 12.35, 7.19 and 11.79 µM against HT-29, HCT-116 and SW-620 cells, respectively^[1].
PDE5/HDAC-IN-1 shows cytotoxic activity with IC₅₀ values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

553.45

Formula

C₂₇H₂₉BrN₄O₄

CAS No.

2414921-48-3

SMILES

O=C1N2[C@@](C3=CC=C(C=C3)Br)([H])C4=C(C[C@]2([H])C(N(C1)CCCCCCC(NO)=O)=O)C5=CC=CC=C5N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. ElHady AK, et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742. [Content Brief]

PDE5/HDAC-IN-1 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE5/HDAC-IN-12414921-48-3Phosphodiesterase (PDE)HDACApoptosisHistone deacetylasesMolt4anticancerleukemia tumorsolid tumorInhibitorinhibitorinhibit

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